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期刊论文
synthesis, structure and antitumor activity of dibutyltin oxide complexes with 5-fluorouracil derivatives. crystal structure of [(5-fluorouracil)-1-ch2ch2coosn(n-bu)2] 4o2
molecules 2001, 6, 647-654，-0001，（）：
dibutyltin (iv) oxide complex reacts with the fluorouracil compounds 5-fluorouracil-1-propanonic or 5-fluorouracil-1-acetic acid (fu) to give the complexes [(5-fu)-1(ch2)ncoosn(n=bu)2]4o2(i,n=2;ii,n=1) which were characterized by ir and 1h-nmr. the crystal structure of complex i shows that the molecular is a dimer, in which two [(5-fu)-1-ch2ch2coosn(n-bu)2] 2o units are linked by a bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from a dibutyl moiety and three oxygen atoms from 5-fu and bridging oxygen. these complexes have potential anti-tumour activity: in vitro tests showed that complexes and ii exhibit high cytotoxicity against ovcar-3 and pc-14.
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