蒋新国
① 新型药物制剂的研制及其体内外评价; ② 药物的脑内靶向递释系统研究。
个性化签名
- 姓名:蒋新国
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
药剂学
- 研究兴趣: ① 新型药物制剂的研制及其体内外评价; ② 药物的脑内靶向递释系统研究。
蒋新国,1982年毕业于上海第一医学院药学专业。现任复旦大学药学院药剂学教研室主任、研究员、博士研究生导师,兼任《中国临床药学杂志》副主编、《中国医院药学杂志》、《儿科药学杂志》编委等。
主要研究方向:
① 新型药物制剂的研制及其体内外评价;
② 药物的脑内靶向递释系统研究。近年来,负责和参加国家自然科学基金课题5项,省部级科研基金课题4项;与企业合作进行新药研制及体内外评价项目56项。
主要研究成果:
① 发表论文100篇,其中sci论文23篇。
② 参编药剂学教材3本。
③ 申请发明专利10项,其中3项已授权,另有3项专利分别获得上海市优秀发明选拔赛一、二、三等奖。
④ 培养博士研究生6名,硕士研究生12名;其中,博士论文《尼莫地平鼻腔给药的脑内递药特性研究》获得2004年上海市研究生优秀成果奖(学位论文)。
⑤ 科研成果“鼻腔给药的脑内靶向性研究”获得2004年上海药学科技二等奖。
⑥ 教学成果“全国高等医药院校教材《药剂学》第三版” 1997年获得上海市科技进步三等奖(第四完成者)。
⑦ 科研成果“海藻酸盐作为缓释制剂辅料的研究” 1995年分别获得卫生部科技进步三等奖和上海市科技进步三等奖(第二完成者)。
⑧ 1995年获得“第二届吴阶平 - 保罗?杨森医药学研究奖” 三等奖。
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2005-08-12
蒋新国, 张奕, 姚洁
issn 0253-9756 acta phamaool sin 中国药理学报 2001 nov; 22 (11): 1045-1050,-0001,():
-1年11月30日
目的:用环糊精改善鼻腔吸收促进剂去氧胆酸钠(sdc)的鼻纤毛毒性方法:分别用红细胞溶血实验、蟾除上模型和扫描电镜观察环糊精对sdc细胞膜破坏作用和鼻纤毛毒性的影响 sdc和β环糊精(β-cd)之间的包合作用采用差示热分析法和x-衍射法进行验证。结果:当sdc与β-cd或二基β环糊精(dm-β-cd)的摩尔比为 1:1 和 1:2 时能完全掩盖sdc的溶血作用。用蟾除上模型评价时,加入摩尔比 1:2 或 1:3 的sdc与β-cd或dm-βcd的混合液使sdc的相对纤毛持续运动时间由原来的0%提高至50%以上,大鼠鼻腔连续给予1:2摩尔比的sdc-β-cd溶液一周后,扫描电镜显示粘膜纤毛无明显改变,差示热分析和x-衍射结果显示sdc能与β-cd开成包合物。结论:加入β-cd或dm-β-cd能显著降低sdc的溶血作用和鼻纤毛毒性,两者的最佳比例是sdc与环糊精摩尔比 1:2。环糊精的这种保护作用与形成包合物有关。
脱氧胆酸, 环糊精类, 红细胞膜 鼻粘膜, 粘膜纤毛清除, 差示扫描量热法
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2005-08-12
蒋新国, 崔景武, 方晓玲, 韦阳**, 悉念朱
药学学报 acia pharmaceutica sintca 1990; 30 (11): 848~853,-0001,():
-1年11月30日
提出一种新的评价方法-在体蟾蜍上模型,研究对乙酰氨基酚、盐酸著罗帕酮等8种药物溶液或混液对纤毛运动的影响 并与扫描电镜法及离体蟾蜍模型比较。结果表明,在体模型简便易行,结果可靠,适用面广,是一种较理想的鼻纤毛毒性评价方法。离体模型不直评价混型及粘稠性药物制剂的鼻纤毛毒性,但能进行受试药物与对照药物的同体比较,对于溶液制剂是一种优良的评价方法。由8种药物的评价结果提示:药物对纤毛运动的影响较普遍,应予重视。
鼻腔给药, 鼻纤毛毒性
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2005-08-12
蒋新国, 张奕, 姚洁
中国药理学报, 2001 nov; 22 (11): 1051-1056,-0001,():
-1年11月30日
目的:评价(β-cd)或二甲基-β-环糊精与脱氧胆酸钠(sdc)联用对胰岛素的吸收促进作用,方法:通过胰岛素降血糖作用来反映其吸收效果;用扫描电镜观察单次给药后的鼻纤毛毒性;测定亮氨酰氨肽栈的活性。结果:0.75%sdc/β-cd(1:2)联用时,鼻腔给予胰岛素产生的降血糖作用相对慢而持久,血糖果最低值为初始的(72.6±2.1)%,血糖-时间曲线在1至4h内较平稳,虽然与0.75%sdc组比较,两组的最低血糖水平有显著性差异,但血糖时间曲线上面积aoc0值无显著性差异(p>0.05)。扫描电镜结果显示大鼠鼻腔给药4h粘膜纤毛无明显改变。0.01% sdc促吸收能力很弱,但仍有纤毛毒性. sdc与β环糊精或二甲基-β坏糊精联用后,亮氨酰氨肽的活性抑制率由89.2%下降至60%-70%。结论:环糊精与sdc联用后,降低了sdc的纤毛毒性,但仍保留了较强的胰岛素吸收促进用用。这种促进作用并不是由于sdc浓度的降低,而是与亮氨酰氨肽的活性被抑制有关。
脱氧胆酸, 环糊精类, 胰岛素, 吸收, 鼻粘膜, 亮氨酰氨肽酶
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2005-08-12
蒋新国, 陆伟
中国临床药学杂志,2002,11(6)384~387,-0001,():
-1年11月30日
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2005-08-12
蒋新国, 王孝俊, 朱芳海, 李正伟*, 奚念朱
药学学报 acta phamaceutica sinica 1994; 29 (4): 306-310,-0001,():
-1年11月30日
以盐酸普罗帕酮、盐酸地尔硫工和硝酸异出梨酯为模型药物,研究它们在不同分子量的海藻酸钠骨架片中的释药规律。结果表明:海藻酸钠的分子量与释药速度间有良好的线性关系。根据这一关系可以预测已知分子量海藻酸钠的释药情况,为海藻酸钠缓解片剂的处方设计及其实际应用提供理论依据。
海藻酸钠, 分子量, 缓释作用, 缓释骨架片
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2005-08-12
蒋新国, jun chen, xinguo jiang*, wenming jiang, ni mei, xiaoling gao, qizhi zhang
j. chen et al./j. chromatogr. b 805 (2004) 169-173,-0001,():
-1年11月30日
a high-performance liquid chromatographic (hplc) method with fluorescence detection has been developed for the determination of rizatriptan in human plasma. following a single-step liquid-liquid extraction with methyl tertiarybutyl ether, the analytes were separated using a mobile phase consisting of 0.05% (v/v) triethylamine in water (adjusting to ph 2.75 with 85% phosphoric acid) and acetonitrile (92:8, v/v). fluorescence detection was performed at an excitation wavelength of 225nm and an emission wavelength of 360nm. the linearity for rizatriptan was within the concentration range of 0.5-50ng/ml. the intra-and inter-day precisions of the method were not more than 8.0%. the lower limit of quantification (lloq) was 0.5ng/ml for rizatriptan. the method was sensitive, simple and repeatable enough to be used in pharmacokinetic studies.
rizatriptan
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2005-08-12
蒋新国, feng wang, xinguo jiang*, wei lu
f. wang et al./international journal of pharmaceutics 263 (2003) 1-7,-0001,():
-1年11月30日
the aim of this paper was to investigate the levels of methotrexate (mtx) in blood and the cerebrospinal fluid (csf) in rats to find out whether there is any direct drug transport from nasal cavity to csf following intranasal administration. methotrexate was administered to male sprague-dawley rats either intranasally or intravenously. drug concentrations were determined from csf and plasma samples collected from the cisterna magna and caudal vein, respectively. to collect csf sample continuously, blank artificial csf was infused into the lateral ventricle. the plasma levels achieved following intranasal administration were significantly lower than those after intravenous administration (p<0.01) were, while csf concentrations achieved after intranasal administration were significantly higher than those after intravenous administration (p<0.01). the ratio of the auccsf value between the intranasal route and the intravenous injection was 13.76, whereas the absolute bioavailability was only 6.3%, the drug targeting index (dti) of nasal route was 21.7. in conclusion, these results showed that the antineoplastic mtx must be directly transported from the nasal cavity into the csf in rats.
cerebrospinal fluid (, csf), , methotrexate, intranasal administration, intravenous administration
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2005-08-12
蒋新国, jun chen, xin guo jiang, lei cai, wei lu, ke pan gao, zheng qi shi, and qi zhiang zhang
arzneim.-forsch/drug res.54, no.4, 203-206 (2004),-0001,():
-1年11月30日
eighteen chinese male subjects com-pleted a single-blind, randomized, three-treatment, theree-period, cross-over study. in each treatment phase, subjects received a single dose of 20mg isosr-bide dinitrate (cas 87-33-2,isdn) intra-venous infusion, 20mg isosorbide 5-mononitrate (cas16051-77-7,5-ismn) tablet or 20 mg isosorbide 5-nibibutrate intravenous infusion. each conseeutive dosing was separated by a washout period of 7 days, following each dosing, venous blood samples were collected over a period of 16h. pladma concentra-tions of isdn and its two active metabo-lites isosorbide 2-monorlitrate (2-ismn), 5-ismn had been measured by a valid-atcd gas chromatographic method. vari-ous pharmacokinetic parameters includ-ing auc0-t. auc0-x, cmax tmax t1/20 ketm and mrt were determined for the three fornulations and fouud to be in good agreement with literatiie values. auco-1 and auc0-x of 5-ismn tablet and intrave-nous infusion were 2694
cas 87-33-2, cas26051-77-7, isosorbide dinitrate, clinicalstudies, pharmacokinetics, relative btoavailability, isosorbide 5-mononitrate, clinical studles, pharmacoki-netics, relative bioavailabillty
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2005-08-12
蒋新国, qizhi zhang, xinguo jiang *, wenming jiang, wei lu, lina su, zhenqi shi
q. zhang et al./international journal of pharmaceutics 275 (2004) 85-96,-0001,():
-1年11月30日
the purpose of this study was to improve the solubility and enhance the brain uptake of nimodipine (nm) in an o/w microemulsion, which was suitable for intranasal delivery. three microemulsion systems stabilized by the nonionic surfactants either cremophor rh 40 or labrasol, and containing a variety of oils, namely isopropyl myristate, labrafil m 1944cs and maisine 35-1 were developed and characterized. the nasal absorption of nm from microemulsion formulation was investigated in rats. the optimal icroemulsion formulation consisted of 8% labrafil m 1944cs, 30% cremophor rh 40/ethanol (3:1) and water, with a maximum solubility of nm up to 6.4mg/ml, droplet size of 30.3
nimodipine, microemulsion, intranasal delivery, solubilization, olfactory pathway, brain targeting
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2005-08-12
蒋新国, zhenqi shi, qizhi zhang, xinguo jiangt*
life sciences xx (2005) xxx-xxx,-0001,():
-1年11月30日
the aim of this paper is to investigate the pharmacokinetic behavior of hydrochloride meptazinol (mep) in plasma, cerebrospinal fluid (csf) and cerebral cortex after intranasal administration (8mg/kg) in male sprague-dawley rats. the pharmacokinetic study of intravenous administration (8mg/kg) was also performed in rats. csf and cerebral cortex samples were collected by serial csf sampling and intracerebral microdialysis, respectively. the concentration of mep in the biological samples was measured by high performance liquid chromatography (hplc). it was determined that the absorption of mep from the nasal cavity to systemic circulation was rapid and complete. the concentration-time profile showed a prolonged duration of mep concentration in csf and cortex following intranasal administration. the ratios of auc values of intranasal to intravenous administrations were 0.96, 1.07 and 1.81 in plasma, csf and cortex dialysate, respectively. in conclusion, intranasal administration of mep is a promising alternative to traditional administration modes. olfactory mucosa did not present intranasal mep another pathway, in addition to systemic absorption, for transport to the brain.
intranasal administration, meptazinol hydrochloride, cerebrospinal fluid, cortex, olfactory pathway, rat
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