施焕中
从事肺脏免疫相关性疾病的基础和临床研究。
个性化签名
- 姓名:施焕中
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
-
学科领域:
内科学
- 研究兴趣:从事肺脏免疫相关性疾病的基础和临床研究。
施焕中,男,1964年10月出生,博士,教授,国家杰出青年科学基金获得者,现任华中科技大学同济医学院附属协和医院呼吸内科主任。
2002年获全国优秀博士论文奖;2004年入选首批新世纪百千万人才工程国家级人选以及国家教育部新世纪优秀人才支持计划,获吴阶平医学研究奖-保罗•杨森药学研究奖,被授予卫生部有突出贡献中青年专家称号,同年起享受国务院政府特殊津贴;2006年获首届中国呼吸医师奖;2007年获中华医学科技奖一等奖;2011年获国家科学技术进步奖二等奖。
自1994年开始从事肺脏免疫相关性疾病的基础和临床研究。主要学术贡献在于:(1) 证实白介素-4和白介素-5可直接导致哮喘患者的气道炎症和气道高反应性,阐述调节性t细胞在哮喘发病的免疫调节活性及其作用机制,发现嗜酸粒细胞在体内能够呈递抗原从而参与哮喘的发病过程,长期致力于推动我国哮喘的规范化治疗。关于哮喘的研究成果“支气管哮喘的发病机制及规范化治疗”获2011年度获国家科学技术进步奖二等奖。(2) 阐述多种t细胞亚群诸如th17、th22、th9细胞及调节性t细胞等在胸腔积液中分布、表型和功能特征;发现这些免疫细胞浸润到胸膜腔的全新机制。(3) 系统探讨多种可溶性介质对于鉴别诊断良恶性胸腔积液的临床价值,为临床使用这些诊断指标提供循证医学依据。
在相关学术领域编著或主编学术专著4部,作为第一作者和/或通讯作者在am j respir crit care med、thorax、chest、eur respir j和j immunol等呼吸医学和免疫学杂志发表科学论文40余篇,所发表论文迄今被sci杂志他引800余次。
-
凯发k8国际首页主页访问
11493
-
关注数
0
-
成果阅读
1112
-
成果数
20
施焕中
,-0001,():
-1年11月30日
-
68浏览
-
0点赞
-
0收藏
-
10分享
-
97下载
-
0评论
-
引用
施焕中
,-0001,():
-1年11月30日
-
82浏览
-
0点赞
-
0收藏
-
9分享
-
206下载
-
0评论
-
引用
施焕中, q zhou, z j ye, y su, j c zhang, h z shi
heart 2010; 96: 1207-1211.,-0001,():
-1年11月30日
background n-terminal pro-brain natriuretic peptide (nt-probnp) is a biomarker useful in diagnosis of pleural effusion due to heart failure. thus far, its overall diagnostic accuracy has not been systematically reviewed. the aim of the present meta-analysis was to establish the overall diagnostic accuracy of the measurement of pleural nt-probnp for identifying pleural effusion due to heart failure. methods after a systematic review of english-language studies, sensitivity, specificity, and other measures of accuracy of nt-probnp concentrations in pleural fluid in the diagnosis of pleural effusion resulting from heart failure were pooled using fixed-effects models. summary receiver operating characteristic curves were used to summarise overall test performance. results eight publications met the inclusion criteria. the summary estimates for pleural nt-probnp in the diagnosis of pleural effusion attributable to heart failure were: sensitivity 0.95 (95% ci 0.92 to 0.97), specificity 0.94 (0.92 to 0.96), positive likelihood ratio 14.12 (10.23 to 19.51), negative likelihood ratio 0.06 (0.04 to 0.09) and diagnostic or 213.87 (122.50 to 373.40). conclusions nt-probnp levels in pleural fluid showed a high diagnostic accuracy and may help accurately differentiate cardiac from non-cardiac conditions in patients presenting with pleural effusion.
-
51浏览
-
0点赞
-
0收藏
-
5分享
-
145下载
-
0评论
-
引用
【期刊论文】generation and differentiation of il-17–producing cd4 t cells in malignant pleural effusion
施焕中, zhi-jian ye, *, qiong zhou, yong-yao gu, ? shou-ming qin, ? wan-li ma, * jian-bao xin, * xiao-nan tao, * and huan-zhong shi*
the journal of immunology th17 cells in mpe,-0001,():
-1年11月30日
il-17–producing cd4 t (th17) cells have been found to be increased in some human cancers; however, the possible implication of th17 cells in regulating antitumor responses in malignant pleural effusion (mpe) remains to be elucidated. in the current study, distribution and phenotypic features of th17 cells in both mpe and peripheral blood from patients with lung cancer were determined by flow cytometry or double immunofluorescence staining. the impacts of cytokines on th17 cell generation and differentiation were explored. the chemoattractant activity of chemokines ccl20 and ccl22 for th17 cells in vitro was also observed. it was found that the increased th17 cells could be found in mpe compared with blood. the in vitro experiments showed that il-1b, il-6, il-23, or their various combinations could promote th17 cell generation and differentiation from naive cd4 t cells. mpe was chemotactic for th17 cells, and this activity was partly blocked by anti-ccl20 and/or ccl22 abs. our data also showed that the accumulation of th17 cells in mpe predicted improved patient survival. it could be concluded that the overrepresentation of th17 cells in mpe might be due to th17 cell differentiation and expansion stimulated by pleural proinflammatory cytokines and to recruitment of th17 cells from peripheral blood induced by pleural chemokines ccl20 and ccl22. furthermore, the accumulation of th17 cells in mpe predicted improved patient survival. these data provide the basis for developing immune-boosting strategies based on ridding the cancer patient of this cell population. the journal of immunology,
-
84浏览
-
0点赞
-
0收藏
-
5分享
-
166下载
-
0评论
-
引用
【期刊论文】epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion
施焕中, g-n. liu*, h-z. shi*, z-h. xie*, h-h. shen#, h-q. huang#, j-m. deng*, q-l. liang* and y-b. wu*
eurr respir j 2009; 34: 184-190,-0001,():
-1年11月30日
the aim of this study was to investigate the presence of epithelial neutrophil-activating peptide (ena)-78 in pleural effusions, as well as the chemoattractant activity of pleural ena-78 0n neutrophils. pleural effusion and serum samples were collected from 75 patients who presented to the respiratory institute (19 with malignant pleural effusion, 21 with tuberculous pleural effusion, 18 with infectious pleural effusion and 17 with transudative pleural effusion). the concentrations of ena-78, myeloperoxidase and neutrophil elastase were determined, and the chemoattractant activity of ena-78 for neutrophils both in vitro and in vivo was also observed. the concentrations of ena-78, myeloperoxidase and neutrophil elastase in infectious pleural effusion were significantly higher than those in malignant, tuberculous and transudative groups, respectively (all p<0.01). infectious pleural fluid was chemotactic for neutrophils in vitro and anti-ena-78 antibody could partly inhibit these chemotactic effects. intrapleural administration of ena-78 produced a marked progressive influx of neutrophils into pleural space. compared with noninfectious pleural effusion, ena-78 appeared to be increased in infectious pleural effusion. our data suggested that ena-78 was able to induce neutrophil infiltration into pleural space and might be responsible for pleural neutrophil degranulation.
infections,, inflammatory cell,, neutrophil migration,, pleural effusion
-
81浏览
-
0点赞
-
0收藏
-
5分享
-
212下载
-
0评论
-
引用
【期刊论文】ccl22 recruits cd4-positive cd25-positive regulatory t cellsinto malignant pleural effusion
施焕中, xue-jun qin, huan-zhong shi, jing-min deng, qiu-li liang, jing jiang, and zhi-jian ye
clin cancewr res 2009; 15(7) april 1, 2009 2231-2237,-0001,():
-1年11月30日
purpose: the aim of this study was to explore the presence of the chemokines ccl22 and ccl17 in malignant pleural effusion, and the chemoattractant activity of these chemokines on cd4-positive cd25-positive foxp3-positive reg ulatory tcells infiltrating into the pleural space. experimental design: the concentrations of ccl22 and ccl17 in both pleural effusions and sera from 33 patients with lung cancer were determined. flow cytometry was done to determine t lymphocyte subsets in cell pellets of pleural effusion. pleural cells were analyzed for the expres-sion of ccl22 and ccl17. the chemoattractant activity of ccl22 for regulatory tcells in vitro and in vivo was also observed. results: the concentration of ccl22 in malignant pleural effusion was significantly higher than that in the corresponding serum. pleural fluid from lung cancer patients was chemotactic for reg-ulatorytcells, and this activity was partly blocked by an anti-ccl22, but not by an anti-ccl17 antibody. intrapleural administration of ccl22 0f patients produced a marked progressive influx of reg ulatory t cells into pleural space. conclusions: compared with serum, ccl22 seemed to be increased in malignant pleural effu-sion, and could directly induce reg ulatory t cell infiltration into the pleural space in patients with malignant effusion.
-
60浏览
-
0点赞
-
0收藏
-
1分享
-
139下载
-
0评论
-
引用
施焕中
,-0001,():
-1年11月30日
-
60浏览
-
0点赞
-
0收藏
-
1分享
-
371下载
-
0评论
-
引用
【期刊论文】diagnostic value of carcinoembryonic antigen in malignant pleural effusion: a meta-analysis
施焕中
,-0001,():
-1年11月30日
-
63浏览
-
0点赞
-
0收藏
-
1分享
-
199下载
-
0评论
-
引用
【期刊论文】diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis
施焕中
,-0001,():
-1年11月30日
-
82浏览
-
0点赞
-
0收藏
-
1分享
-
242下载
-
0评论
-
引用
【期刊论文】diagnostic accuracy of tumour markers for malignant pleural effusion: a meta-analysis
施焕中
,-0001,():
-1年11月30日
-
66浏览
-
0点赞
-
0收藏
-
1分享
-
169下载
-
0评论
-
引用